VectorSelect Platform
engineering cellular systems for a new era of medicine
We’re reprogramming cellular output for the production of next generation medicines. Our platform powers the discovery, design, and optimization of the entire production stack — from cell lines to media and beyond.
Unlocking next generation medicines with intelligent biology and scalable design
Why
Next generation medicines aren’t struggling because the science is broken, they’re struggling because the production systems haven’t kept pace. Low yield manufacturing and limited capacity continue to slow down drug development and restrict access to promising therapies. In some cases, entire programs may be sidelined simply because they can’t be produced efficiently at scale.
What
VectorSelect is built to shift these economics. Our platform develops high performing cell lines and other production technologies designed to boost yield and improve efficiency.
How
We develop robust, flexible base cell lines and run parallel discovery efforts to identify the most impactful genetic and process optimizations. These data feed into VectorSelect’s cell map — a growing atlas that reveals the cellular programs driving yield and informs each subsequent iteration — powering a platform designed to accelerate development, reduce cost, and expand access to therapies currently out of reach.
01
Base cell line optimization
Develop and tune a variety of production cell lines for flexible plasmid requirements.
- Transient cell lines
- Stable cell lines
02
Perturbation discovery
Discover the best genetic perturbations and combinations thereof to install into cell lines for maximum productivity and quality.
Proprietary barcoding technology links each parent cell’s genotype and yield, enabling massively parallel genome scale pooled screens. By assaying multiple orders of magnitude more mutants in a single experiment than is possible in multiwell format, we uncover key genetic pathways that drive productivity. These insights flow into VectorSelect’s cell map to guide the best combinations to install into the base cell line.
03
Process
discovery
Discover the best media additives and optimized processes for maximum productivity and quality.
Metabolic insights from perturbation discovery and complementary technologies reveal key metabolic pathways that impact cell line productivity. This informs downstream testing of media additives and other parameters at various scales. These findings feed into VectorSelect’s cell map to surface the best media formulations and conditions for further increased productivity of our engineered cell lines.
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04
Cell MaP
Integrate genetic and process data to guide the next round of engineering for even higher productivity and quality.
VectorSelect’s cell map is a growing atlas of genetic and metabolic pathway insights linked to production phenotypes, continuously enriched by perturbation and process discovery data. We computationally mine it in two ways: genetic mapping filters the vast combinatorial space of perturbations into screenable sets with higher yield potential; metabolic mapping identifies routes for media and process optimization to further enhance productivity.
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Iterative loops drive compounding improvements
We iterate through the platform to further optimize production cell lines for yield, quality and other key performance metrics.